Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique

Yamaguchi, Isao; Kidoya, Eiji; Suzuki, Masayuki; Kimura, Hirohiko

doi:10.1016/j.compmedimag.2008.09.005

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Volume 33, Issue 1 , Pages 23-28, January 2009

Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique

Isao Yamaguchi
- Radiological Center, University of Fukui Hospital, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan
- Division of Health Sciences, Kanazawa University Graduate School of Medicine Science, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan
- Corresponding author at: Radiological Center, University of Fukui Hospital, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan. Tel.: +81 776 61 3111; fax: +81 776 61 8154.
Eiji Kidoya
- Radiological Center, University of Fukui Hospital, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan
- Tel.: +81 776 61 3111.
Masayuki Suzuki
- Division of Health Sciences, Kanazawa University Graduate School of Medicine Science, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan
- Tel.: +81 76 265 2500.
Hirohiko Kimura
- Department of Radiology, Facility of Medical Sciences, University of Fukui, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan
- Tel.: +81 776 61 3111.

Received 30 June 2008; accepted 29 September 2008.

Abstract

The present study was performed to find the required volume of physiological saline for flushing that will allow the most efficient use of contrast medium during the early phase of dynamic CT. We calculated contrast medium aortic arrival time (AT), time to peak aortic enhancement (TPAE) and the elapsed time to TPAE from AT (rise time) from the TECs of pharmacokinetic analysis and clinical study. The rise time determined in the clinical study was 6.2s, which was shorter than that in the simulation study. In the present study, an appropriate volume for saline flush was estimated to be about 18ml.